2ol9
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2ol9.gif|left|200px]] | + | [[Image:2ol9.gif|left|200px]] |
| - | + | ||
| - | '''Peptide corresponding to residues 170-175 of human prion''' | + | {{Structure |
| + | |PDB= 2ol9 |SIZE=350|CAPTION= <scene name='initialview01'>2ol9</scene>, resolution 0.850Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Peptide corresponding to residues 170-175 of human prion''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2OL9 is a [ | + | 2OL9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OL9 OCA]. |
==Reference== | ==Reference== | ||
| - | Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http:// | + | Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17468747 17468747] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Apostol, M A.]] | [[Category: Apostol, M A.]] | ||
| Line 18: | Line 27: | ||
[[Category: steric zipper]] | [[Category: steric zipper]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:01:11 2008'' |
Revision as of 16:01, 20 March 2008
| |||||||
| , resolution 0.850Å | |||||||
|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Peptide corresponding to residues 170-175 of human prion
Overview
Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
About this Structure
2OL9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747
Page seeded by OCA on Thu Mar 20 18:01:11 2008
