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4mvt

From Proteopedia

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m (Protected "4mvt" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4mvt| PDB=4mvt | SCENE= }}
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===Crystal structure of SUMO E3 Ligase PIAS3===
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The entry 4mvt is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PIAS3_HUMAN PIAS3_HUMAN]] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.<ref>PMID:9388184</ref>
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Authors: Dong, A., Hu, J., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4mvt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVT OCA].
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Description: Crystal structure of SUMO E3 Ligase PIAS3
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Dong, A.]]
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[[Category: Edwards, A M.]]
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[[Category: Hu, J.]]
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[[Category: Li, Y.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel, W.]]
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[[Category: Tong, Y.]]
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[[Category: E3 ligase]]
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[[Category: Ligase]]
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[[Category: Pinit domain]]
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[[Category: Sgc]]
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[[Category: Sp-ring domain]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Sumo]]

Revision as of 08:12, 16 October 2013

Template:STRUCTURE 4mvt

Contents

Crystal structure of SUMO E3 Ligase PIAS3

Function

[PIAS3_HUMAN] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.[1]

About this Structure

4mvt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Chung CD, Liao J, Liu B, Rao X, Jay P, Berta P, Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5. PMID:9388184

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OCA

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