2ong
From Proteopedia
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| - | [[Image:2ong.gif|left|200px]] | + | [[Image:2ong.gif|left|200px]] |
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| - | '''Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).''' | + | {{Structure |
| + | |PDB= 2ong |SIZE=350|CAPTION= <scene name='initialview01'>2ong</scene>, resolution 2.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FPG:(1S)-1-[(1R)-1-FLUOROETHYL]-1,5-DIMETHYLHEXYL+TRIHYDROGEN+DIPHOSPHATE'>FPG</scene> and <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ONG is a [ | + | 2ONG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mentha_spicata Mentha spicata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONG OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:[http:// | + | Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17372193 17372193] |
[[Category: Mentha spicata]] | [[Category: Mentha spicata]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: monoterpene synthase]] | [[Category: monoterpene synthase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:01:58 2008'' |
Revision as of 16:02, 20 March 2008
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| , resolution 2.7Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).
Overview
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.
About this Structure
2ONG is a Single protein structure of sequence from Mentha spicata. Full crystallographic information is available from OCA.
Reference
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193
Page seeded by OCA on Thu Mar 20 18:01:58 2008
