2onh

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[[Image:2onh.gif|left|200px]]<br /><applet load="2onh" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2onh.gif|left|200px]]
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caption="2onh, resolution 2.7&Aring;" />
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'''Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)'''<br />
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{{Structure
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|PDB= 2onh |SIZE=350|CAPTION= <scene name='initialview01'>2onh</scene>, resolution 2.7&Aring;
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|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+601'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+602'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Residue+A+603'>AC3</scene>, <scene name='pdbsite=AC4:Mn+Binding+Site+For+Residue+B+1601'>AC4</scene>, <scene name='pdbsite=AC5:Mn+Binding+Site+For+Residue+B+1602'>AC5</scene>, <scene name='pdbsite=AC6:Mn+Binding+Site+For+Residue+B+1603'>AC6</scene>, <scene name='pdbsite=AC7:F3p+Binding+Site+For+Residue+A+600'>AC7</scene>, <scene name='pdbsite=AC8:Btb+Binding+Site+For+Residue+A+604'>AC8</scene> and <scene name='pdbsite=AC9:F3p+Binding+Site+For+Residue+B+1600'>AC9</scene>
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=F3P:(1S)-1-[(1S)-1-FLUOROETHYL]-1,5-DIMETHYLHEXYL+TRIHYDROGEN+DIPHOSPHATE'>F3P</scene> and <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2ONH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mentha_spicata Mentha spicata] with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=F3P:'>F3P</scene> and <scene name='pdbligand=BTB:'>BTB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+601'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+602'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Residue+A+603'>AC3</scene>, <scene name='pdbsite=AC4:Mn+Binding+Site+For+Residue+B+1601'>AC4</scene>, <scene name='pdbsite=AC5:Mn+Binding+Site+For+Residue+B+1602'>AC5</scene>, <scene name='pdbsite=AC6:Mn+Binding+Site+For+Residue+B+1603'>AC6</scene>, <scene name='pdbsite=AC7:F3p+Binding+Site+For+Residue+A+600'>AC7</scene>, <scene name='pdbsite=AC8:Btb+Binding+Site+For+Residue+A+604'>AC8</scene> and <scene name='pdbsite=AC9:F3p+Binding+Site+For+Residue+B+1600'>AC9</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONH OCA].
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2ONH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mentha_spicata Mentha spicata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONH OCA].
==Reference==
==Reference==
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Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17372193 17372193]
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Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17372193 17372193]
[[Category: Mentha spicata]]
[[Category: Mentha spicata]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: monoterpene synthase]]
[[Category: monoterpene synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:01:59 2008''

Revision as of 16:02, 20 March 2008

Image:2onh.gif


PDB ID 2onh

Drag the structure with the mouse to rotate
, resolution 2.7Å
Sites: , , , , , , , and
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)


Overview

The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.

About this Structure

2ONH is a Single protein structure of sequence from Mentha spicata. Full crystallographic information is available from OCA.

Reference

Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193

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