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4fl9

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{{STRUCTURE_4fl9| PDB=4fl9 | SCENE= }}
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==Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution==
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===Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution===
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<StructureSection load='4fl9' size='340' side='right' caption='[[4fl9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4fl9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FL9 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yuw|1yuw]]</td></tr>
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==About this Structure==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPA8, HSC70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
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[[4fl9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL9 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fl9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fl9 RCSB], [http://www.ebi.ac.uk/pdbsum/4fl9 PDBsum]</span></td></tr>
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</table>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Grimm, C.]]
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[[Category: Grimm, C]]
[[Category: Heat shock protein]]
[[Category: Heat shock protein]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 11:17, 21 December 2014

Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution

4fl9, resolution 1.90Å

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