4kbm

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{{STRUCTURE_4kbm| PDB=4kbm | SCENE= }}
{{STRUCTURE_4kbm| PDB=4kbm | SCENE= }}
===Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex===
===Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex===
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{{ABSTRACT_PUBMED_24055315}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024055315</ref><references group="xtra"/><references/>
[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]

Revision as of 05:15, 10 October 2013

Template:STRUCTURE 4kbm

Contents

Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex

Template:ABSTRACT PUBMED 24055315

Function

[RPOB_MYCTU] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [CARD_MYCTU] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.[1] [2]

About this Structure

4kbm is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Gulten G, Sacchettini JC. Structure of the Mtb CarD/RNAP beta-Lobes Complex Reveals the Molecular Basis of Interaction and Presents a Distinct DNA-Binding Domain for Mtb CarD. Structure. 2013 Sep 17. pii: S0969-2126(13)00306-7. doi:, 10.1016/j.str.2013.08.014. PMID:24055315 doi:http://dx.doi.org/10.1016/j.str.2013.08.014
  1. ↑ Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041. PMID:19596241 doi:10.1016/j.cell.2009.04.041
  2. ↑ Weiss LA, Harrison PG, Nickels BE, Glickman MS, Campbell EA, Darst SA, Stallings CL. Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol. 2012 Oct;194(20):5621-31. Epub 2012 Aug 17. PMID:22904282 doi:10.1128/JB.00879-12

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OCA

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