4m44
From Proteopedia
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| - | + | ==Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa== | |
| - | + | <StructureSection load='4m44' size='340' side='right' caption='[[4m44]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4m44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/yamanashi/166/1998) Influenza b virus (b/yamanashi/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M44 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m40|4m40]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416659 Influenza B virus (B/Yamanashi/166/1998)])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m44 RCSB], [http://www.ebi.ac.uk/pdbsum/4m44 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Influenza A and B viruses are responsible for the severe morbidity and mortality worldwide in annual influenza epidemics. Currently circulating influenza B virus belongs to the B/Victoria or B/Yamagata lineage that was diverged from each other about 30-40 years ago. However, a mechanistic understanding of their divergent evolution is still lacking. Here we report the crystal structures of influenza B/Yamanashi/166/1998 hemagglutinin (HA) belonging to B/Yamagata lineage and its complex with the avian-like receptor analogue. Comparison of these structures with those of undiverged and diverged influenza B virus HAs, in conjunction with sequence analysis, reveals the molecular basis for the divergent evolution of influenza B virus HAs. Furthermore, HAs of diverged influenza B virus strains display much stronger molecular interactions with terminal sialic acid of bound receptors, which may allow for a different tissue tropism for current influenza B viruses, for which further investigation is required. | ||
| - | + | Structural basis for the divergent evolution of influenza B virus hemagglutinin.,Ni F, Kondrashkina E, Wang Q Virology. 2013 Nov;446(1-2):112-22. doi: 10.1016/j.virol.2013.07.035. Epub 2013, Aug 27. PMID:24074573<ref>PMID:24074573</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Kondrashkina, E | + | |
| - | [[Category: Ni, F | + | ==See Also== |
| - | [[Category: Wang, Q | + | *[[Hemagglutinin|Hemagglutinin]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kondrashkina, E]] | ||
| + | [[Category: Ni, F]] | ||
| + | [[Category: Wang, Q]] | ||
[[Category: Fusion]] | [[Category: Fusion]] | ||
[[Category: Receptor binding]] | [[Category: Receptor binding]] | ||
[[Category: Sialic acid]] | [[Category: Sialic acid]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 15:14, 21 December 2014
Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa
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