4c1q

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'''Unreleased structure'''
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{{STRUCTURE_4c1q| PDB=4c1q | SCENE= }}
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===Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.===
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{{ABSTRACT_PUBMED_24095733}}
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The entry 4c1q is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PRDM9_MOUSE PRDM9_MOUSE]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase.
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Authors: Mathioudakis, N., Cusack, S., Kadlec, J.
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==About this Structure==
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[[4c1q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1Q OCA].
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Description: Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.
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==Reference==
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<ref group="xtra">PMID:024095733</ref><references group="xtra"/><references/>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Mus musculus]]
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[[Category: Cusack, S.]]
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[[Category: Kadlec, J.]]
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[[Category: Mathioudakis, N.]]
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[[Category: Histone methyltransferase]]
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[[Category: Set domain h3k4me3]]
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[[Category: Transferase-peptide complex]]

Revision as of 08:01, 16 October 2013

Template:STRUCTURE 4c1q

Contents

Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.

Template:ABSTRACT PUBMED 24095733

Function

[PRDM9_MOUSE] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase.

About this Structure

4c1q is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9. Cell Rep. 2013 Oct 2. pii: S2211-1247(13)00476-2. doi:, 10.1016/j.celrep.2013.08.035. PMID:24095733 doi:http://dx.doi.org/10.1016/j.celrep.2013.08.035

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