4mze

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m (Protected "4mze" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4mze| PDB=4mze | SCENE= }}
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===Crystal structure of hPIV3 hemagglutinin-neuraminidase, H552Q/Q559R mutant===
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{{ABSTRACT_PUBMED_24149514}}
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The entry 4mze is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/HN_PI3H4 HN_PI3H4]] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
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Authors: Xu, R., Wilson, I.A.
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==About this Structure==
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[[4mze]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_parainfluenza_3_virus_(strain_nih_47885) Human parainfluenza 3 virus (strain nih 47885)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZE OCA].
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Description: Crystal structure of hPIV3 hemagglutinin-neuraminidase, H552Q/Q559R mutant
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==Reference==
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<ref group="xtra">PMID:024149514</ref><references group="xtra"/><references/>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Wilson, I A.]]
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[[Category: Xu, R.]]
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[[Category: Hydrolase]]
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[[Category: Viral envelope protein]]
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[[Category: Viral fusion protein]]

Revision as of 07:54, 6 November 2013

Template:STRUCTURE 4mze

Contents

Crystal structure of hPIV3 hemagglutinin-neuraminidase, H552Q/Q559R mutant

Template:ABSTRACT PUBMED 24149514

Function

[HN_PI3H4] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).

About this Structure

4mze is a 2 chain structure with sequence from Human parainfluenza 3 virus (strain nih 47885). Full crystallographic information is available from OCA.

Reference

  • Xu R, Palmer SG, Porotto M, Palermo LM, Niewiesk S, Wilson IA, Moscona A. Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo. MBio. 2013 Oct 22;4(5). pii: e00803-13. doi: 10.1128/mBio.00803-13. PMID:24149514 doi:http://dx.doi.org/10.1128/mBio.00803-13

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OCA

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