4n0e

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m (Protected "4n0e" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4n0e| PDB=4n0e | SCENE= }}
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===Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP===
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The entry 4n0e is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
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Authors: Thaker, T.M., Preininger, A.M., Sarwar, M., Hamm, H.E., Iverson, T.M.
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==About this Structure==
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[[4n0e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0E OCA].
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Description: Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Heterotrimeric G-protein GTPase]]
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[[Category: Hamm, H E.]]
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[[Category: Iverson, T M.]]
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[[Category: Preininger, A M.]]
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[[Category: Sarwar, M.]]
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[[Category: Thaker, T M.]]
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[[Category: Gdp]]
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[[Category: Gtp]]
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[[Category: Guanine nucleotide binding protein]]
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[[Category: Hydrolase]]
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[[Category: Magnesium binding]]
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[[Category: Rossman fold]]

Revision as of 14:01, 12 March 2014

Template:STRUCTURE 4n0e

Contents

Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP

Function

[GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.[1]

About this Structure

4n0e is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Shu FJ, Ramineni S, Amyot W, Hepler JR. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25. PMID:16870394 doi:http://dx.doi.org/10.1016/j.cellsig.2006.06.002

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OCA

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