We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
4ioz
From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | {{STRUCTURE_4ioz| PDB=4ioz | SCENE= }}
| + | #REDIRECT [[4o9b]] This PDB entry is obsolete and replaced by 4o9b |
| - | ===The Structure of CC1-IH in human STIM1.===
| + | |
| - | {{ABSTRACT_PUBMED_24069340}}
| + | |
| - | | + | |
| - | ==Disease==
| + | |
| - | [[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[http://omim.org/entry/612783 612783]]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref> | + | |
| - | | + | |
| - | ==Function==
| + | |
| - | [[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref> <ref>PMID:16005298</ref> <ref>PMID:15866891</ref> <ref>PMID:16208375</ref> <ref>PMID:16807233</ref> <ref>PMID:16766533</ref> <ref>PMID:16733527</ref> <ref>PMID:16537481</ref> <ref>PMID:22464749</ref>
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | [[4ioz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOZ OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | <ref group="xtra">PMID:024069340</ref><references group="xtra"/><references/>
| + | |
| - | [[Category: Homo sapiens]]
| + | |
| - | [[Category: Cui, B.]]
| + | |
| - | [[Category: Li, S.]]
| + | |
| - | [[Category: Shen, Y.]]
| + | |
| - | [[Category: Yang, X.]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Signalling]]
| + | |
Current revision
- REDIRECT 4o9b This PDB entry is obsolete and replaced by 4o9b
