This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4ioz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:07, 15 January 2014) (edit) (undo)
(Redirecting to 4o9b)
 
Line 1: Line 1:
-
{{STRUCTURE_4ioz| PDB=4ioz | SCENE= }}
+
#REDIRECT [[4o9b]] This PDB entry is obsolete and replaced by 4o9b
-
===The Structure of CC1-IH in human STIM1.===
+
-
{{ABSTRACT_PUBMED_24069340}}
+
-
 
+
-
==Disease==
+
-
[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[http://omim.org/entry/612783 612783]]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref>
+
-
 
+
-
==Function==
+
-
[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref> <ref>PMID:16005298</ref> <ref>PMID:15866891</ref> <ref>PMID:16208375</ref> <ref>PMID:16807233</ref> <ref>PMID:16766533</ref> <ref>PMID:16733527</ref> <ref>PMID:16537481</ref> <ref>PMID:22464749</ref>
+
-
 
+
-
==About this Structure==
+
-
[[4ioz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOZ OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:024069340</ref><references group="xtra"/><references/>
+
-
[[Category: Homo sapiens]]
+
-
[[Category: Cui, B.]]
+
-
[[Category: Li, S.]]
+
-
[[Category: Shen, Y.]]
+
-
[[Category: Yang, X.]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Signalling]]
+

Current revision

  1. REDIRECT 4o9b This PDB entry is obsolete and replaced by 4o9b

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ioz"
Personal tools