2ow3
From Proteopedia
(New page: 200px<br /><applet load="2ow3" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ow3, resolution 2.80Å" /> '''Glycogen synthase ki...) |
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| - | [[Image:2ow3.jpg|left|200px]] | + | [[Image:2ow3.jpg|left|200px]] |
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| - | '''Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor''' | + | {{Structure |
| + | |PDB= 2ow3 |SIZE=350|CAPTION= <scene name='initialview01'>2ow3</scene>, resolution 2.80Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Bim+Binding+Site+For+Residue+A+387'>AC1</scene> and <scene name='pdbsite=AC2:Bim+Binding+Site+For+Residue+B+387'>AC2</scene> | ||
| + | |LIGAND= <scene name='pdbligand=BIM:'>BIM</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] | ||
| + | |GENE= GSK3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OW3 is a [ | + | 2OW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW3 OCA]. |
==Reference== | ==Reference== | ||
| - | Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:[http:// | + | Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17350261 17350261] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:05:16 2008'' |
Revision as of 16:05, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Sites: | and | ||||||
| Ligands: | |||||||
| Gene: | GSK3B (Homo sapiens) | ||||||
| Activity: | [Tau_protein_kinase [Tau protein] kinase], with EC number 2.7.11.26 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor
Overview
Novel bis(indolyl)maleimide pyridinophanes 3, 9a, 9b, 10a, 10b, and 11 were prepared by cobalt-mediated [2+2+2] cycloaddition of an appropriate alpha,omega-diyne with an N,N-dialkylcyanamide. These macrocyclic heterophanes were found to be potent, selective inhibitors of glycogen synthase kinase-3beta. An X-ray structure of a co-crystal of GSK-3beta and 3 (IC(50)=3nM) depicts the hydrogen bonding and hydrophobic interactions in the ATP-binding pocket of this serine/threonine protein kinase.
About this Structure
2OW3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:17350261[[Category: [Tau protein] kinase]]
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