4by9
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{STRUCTURE_4by9| PDB=4by9 | SCENE= }} | {{STRUCTURE_4by9| PDB=4by9 | SCENE= }} | ||
===The structure of the Box CD enzyme reveals regulation of rRNA methylation=== | ===The structure of the Box CD enzyme reveals regulation of rRNA methylation=== | ||
| + | {{ABSTRACT_PUBMED_24121435}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. | [[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024121435</ref><references group="xtra"/><references/> | ||
[[Category: Pyrococcus furiosus]] | [[Category: Pyrococcus furiosus]] | ||
[[Category: Carlomagno, T.]] | [[Category: Carlomagno, T.]] | ||
Revision as of 05:14, 23 October 2013
Contents |
The structure of the Box CD enzyme reveals regulation of rRNA methylation
Template:ABSTRACT PUBMED 24121435
Function
[FLPA_PYRFU] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).[HAMAP-Rule:MF_00351] [RL7A_PYRFU] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).
About this Structure
4by9 is a 18 chain structure with sequence from Pyrococcus furiosus. Full experimental information is available from OCA.
Reference
- Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T. The structure of the box C/D enzyme reveals regulation of RNA methylation. Nature. 2013 Oct 13. doi: 10.1038/nature12581. PMID:24121435 doi:http://dx.doi.org/10.1038/nature12581
