4lfh

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{{STRUCTURE_4lfh| PDB=4lfh | SCENE= }}
 
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===Crystal Structure of 9C2 TCR===
 
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{{ABSTRACT_PUBMED_24076636}}
 
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==About this Structure==
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==Crystal Structure of 9C2 TCR==
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[[4lfh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LFH OCA].
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<StructureSection load='4lfh' size='340' side='right' caption='[[4lfh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lfh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LFH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lhu|4lhu]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lfh OCA], [http://pdbe.org/4lfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lfh RCSB], [http://www.ebi.ac.uk/pdbsum/4lfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lfh ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The T cell repertoire comprises alphabeta and gammadelta T cell lineages. Although it is established how alphabeta T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for gammadelta TCRs. We describe a population of human Vdelta1+ gammadelta T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a gammadelta TCR binds CD1d-alpha-galactosylceramide (alpha-GalCer). The gammadelta TCR docked orthogonally, over the A' pocket of CD1d, in which the Vdelta1-chain, and in particular the germ line-encoded CDR1delta loop, dominated interactions with CD1d. The TCR gamma-chain sat peripherally to the interface, with the CDR3gamma loop representing the principal determinant for alpha-GalCer specificity. Accordingly, we provide insight into how a gammadelta TCR binds specifically to a lipid-loaded antigen-presenting molecule.
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==Reference==
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CD1d-lipid antigen recognition by the gammadelta TCR.,Uldrich AP, Le Nours J, Pellicci DG, Gherardin NA, McPherson KG, Lim RT, Patel O, Beddoe T, Gras S, Rossjohn J, Godfrey DI Nat Immunol. 2013 Sep 29. doi: 10.1038/ni.2713. PMID:24076636<ref>PMID:24076636</ref>
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<ref group="xtra">PMID:024076636</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Godfrey, D I.]]
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</div>
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[[Category: Gras, S.]]
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<div class="pdbe-citations 4lfh" style="background-color:#fffaf0;"></div>
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[[Category: Nours, J Le.]]
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== References ==
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[[Category: Pellicci, D G.]]
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<references/>
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[[Category: Rossjohn, J.]]
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__TOC__
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[[Category: Uldrich, A P.]]
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</StructureSection>
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[[Category: Human]]
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[[Category: Godfrey, D I]]
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[[Category: Gras, S]]
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[[Category: Nours, J Le]]
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[[Category: Pellicci, D G]]
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[[Category: Rossjohn, J]]
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[[Category: Uldrich, A P]]
[[Category: Cd1d]]
[[Category: Cd1d]]
[[Category: Gammadelta tcr]]
[[Category: Gammadelta tcr]]

Revision as of 16:51, 4 August 2016

Crystal Structure of 9C2 TCR

4lfh, resolution 2.30Å

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