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4mr3

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'''Unreleased structure'''
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{{STRUCTURE_4mr3| PDB=4mr3 | SCENE= }}
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===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)===
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{{ABSTRACT_PUBMED_24248379}}
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The entry 4mr3 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)
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==About this Structure==
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[[4mr3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR3 OCA].
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==Reference==
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<ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Fedorov, O.]]
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[[Category: Felletar, I.]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp, S.]]
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[[Category: Martin, S.]]
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[[Category: Picaud, S.]]
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[[Category: Weigelt, J.]]
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[[Category: Brd]]
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[[Category: Brd4]]
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[[Category: Cap]]
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[[Category: Hunk1]]
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[[Category: Mcap]]
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[[Category: Mitotic chromosome associated protein]]
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[[Category: Rvx-oh]]
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[[Category: Sgc]]
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[[Category: Small molecule inhibitor]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription-transcription inhibitor complex]]

Revision as of 10:20, 27 November 2013

Template:STRUCTURE 4mr3

Contents

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)

Template:ABSTRACT PUBMED 24248379

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4mr3 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Picaud S, Wells C, Felletar I, Brotherton D, Martin S, Savitsky P, Diez-Dacal B, Philpott M, Bountra C, Lingard H, Fedorov O, Muller S, Brennan PE, Knapp S, Filippakopoulos P. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013 Nov 18. PMID:24248379 doi:http://dx.doi.org/10.1073/pnas.1310658110
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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