4mxv
From Proteopedia
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| - | + | {{STRUCTURE_4mxv| PDB=4mxv | SCENE= }} | |
| + | ===Structure of Lymphotoxin alpha bound to anti-LTa Fab=== | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. | ||
| - | + | ==About this Structure== | |
| + | [[4mxv]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXV OCA]. | ||
| + | [[Category: Hymowitz, S G.]] | ||
| + | [[Category: Yin, J P.]] | ||
| + | [[Category: Auto-immunity]] | ||
| + | [[Category: Cytokine-immune system complex]] | ||
| + | [[Category: Lymphoid development]] | ||
| + | [[Category: Lymphotoxin alpha]] | ||
| + | [[Category: Lymphotoxin beta receptor]] | ||
| + | [[Category: Tnf]] | ||
| + | [[Category: Tnfr receptor]] | ||
| + | [[Category: Tumor immunity]] | ||
| + | [[Category: Tumor necrosis factor]] | ||
Revision as of 08:32, 13 November 2013
Contents |
Structure of Lymphotoxin alpha bound to anti-LTa Fab
Disease
[TNFB_HUMAN] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Function
[TNFB_HUMAN] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
About this Structure
4mxv is a 9 chain structure. Full crystallographic information is available from OCA.
