4mz6

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'''Unreleased structure'''
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{{STRUCTURE_4mz6| PDB=4mz6 | SCENE= }}
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===Structure of importin-alpha: dUTPase S11E NLS mutant complex===
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The entry 4mz6 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref> [[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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Authors: Marfori, M., Rona, G., Vertessy, B.G., Kobe, B.
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==About this Structure==
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[[4mz6]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4fds 4fds]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ6 OCA].
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Description: Structure of importin-alpha: dUTPase S11E NLS mutant complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Kobe, B.]]
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[[Category: Marfori, M.]]
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[[Category: Rona, G.]]
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[[Category: Vertessy, B G.]]
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[[Category: Arm repeat]]
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[[Category: Importin]]
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[[Category: Nucleus]]
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[[Category: Protein transport]]

Revision as of 08:12, 13 November 2013

Template:STRUCTURE 4mz6

Contents

Structure of importin-alpha: dUTPase S11E NLS mutant complex

Function

[DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[1] [IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

About this Structure

4mz6 is a 3 chain structure. This structure supersedes the now removed PDB entry 4fds. Full crystallographic information is available from OCA.

Reference

  1. ↑ Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15;4(9):1077-92. PMID:8805593

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