4n3t

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m (Protected "4n3t" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4n3t| PDB=4n3t | SCENE= }}
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===Candida albicans Superoxide Dismutase 5 (SOD5), Cu(I)===
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The entry 4n3t is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL]] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.<ref>PMID:14617819</ref> <ref>PMID:19019164</ref> <ref>PMID:21746956</ref>
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Authors: Galaleldeen, A., Taylor, A.B., Waninger-Saroni, J.J., Holloway, S.P., Hart, P.J.
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==About this Structure==
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[[4n3t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3T OCA].
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Description: Candida albicans Superoxide Dismutase 5, Cu(I)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Galaleldeen, A.]]
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[[Category: Hart, P J.]]
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[[Category: Holloway, S P.]]
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[[Category: Taylor, A B.]]
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[[Category: Waninger-Saroni, J J.]]
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[[Category: Antioxidant]]
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[[Category: Disulfide bond]]
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[[Category: Extracellular]]
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[[Category: Oxidative burst]]
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[[Category: Oxidoreductase]]
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[[Category: Zinc loop]]

Revision as of 06:44, 9 April 2014

Template:STRUCTURE 4n3t

Contents

Candida albicans Superoxide Dismutase 5 (SOD5), Cu(I)

Function

[SOD5_CANAL] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.[1] [2] [3]

About this Structure

4n3t is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Martchenko M, Alarco AM, Harcus D, Whiteway M. Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene. Mol Biol Cell. 2004 Feb;15(2):456-67. Epub 2003 Nov 14. PMID:14617819 doi:http://dx.doi.org/10.1091/mbc.E03-03-0179
  2. ↑ Frohner IE, Bourgeois C, Yatsyk K, Majer O, Kuchler K. Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Mol Microbiol. 2009 Jan;71(1):240-52. doi: 10.1111/j.1365-2958.2008.06528.x. Epub, 2008 Nov 4. PMID:19019164 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06528.x
  3. ↑ Bink A, Vandenbosch D, Coenye T, Nelis H, Cammue BP, Thevissen K. Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole. Antimicrob Agents Chemother. 2011 Sep;55(9):4033-7. doi: 10.1128/AAC.00280-11., Epub 2011 Jul 11. PMID:21746956 doi:http://dx.doi.org/10.1128/AAC.00280-11

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