4lp5
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_4lp5| PDB=4lp5 | SCENE= }} | {{STRUCTURE_4lp5| PDB=4lp5 | SCENE= }} | ||
===Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment)=== | ===Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment)=== | ||
| + | {{ABSTRACT_PUBMED_24119142}} | ||
==Function== | ==Function== | ||
| Line 9: | Line 10: | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024119142</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Andersen, G R.]] | [[Category: Andersen, G R.]] | ||
Revision as of 08:18, 30 October 2013
Contents |
Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment)
Template:ABSTRACT PUBMED 24119142
Function
[RAGE_HUMAN] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.[1]
About this Structure
4lp5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Yatime L, Andersen GR. Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products. FEBS J. 2013 Oct 4. doi: 10.1111/febs.12556. PMID:24119142 doi:http://dx.doi.org/10.1111/febs.12556
- ↑ Fang F, Lue LF, Yan S, Xu H, Luddy JS, Chen D, Walker DG, Stern DM, Yan S, Schmidt AM, Chen JX, Yan SS. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB J. 2010 Apr;24(4):1043-55. doi: 10.1096/fj.09-139634. Epub 2009 Nov 11. PMID:19906677 doi:10.1096/fj.09-139634
