2p8h

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[[Image:2p8h.jpg|left|200px]]<br /><applet load="2p8h" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2p8h.jpg|left|200px]]
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caption="2p8h, resolution 1.80&Aring;" />
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'''Crystal structure of human beta secretase complexed with inhibitor'''<br />
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==About this Structure==
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{{Structure
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2P8H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MY9:'>MY9</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8H OCA].
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|PDB= 2p8h |SIZE=350|CAPTION= <scene name='initialview01'>2p8h</scene>, resolution 1.80&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MY9:N-{(1S,2S)-1-BENZYL-2-HYDROXY-2-[(4S)-1,2,2-TRIMETHYL-5-OXOIMIDAZOLIDIN-4-YL]ETHYL}-N'-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-5-[METHYL(METHYLSULFONYL)AMINO]ISOPHTHALAMIDE'>MY9</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]
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|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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==Reference==
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'''Crystal structure of human beta secretase complexed with inhibitor'''
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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1., Barrow JC, Rittle KE, Ngo PL, Selnick HG, Graham SL, Pitzenberger SM, McGaughey GB, Colussi D, Lai MT, Huang Q, Tugusheva K, Espeseth AS, Simon AJ, Munshi SK, Vacca JP, ChemMedChem. 2007 Jul 9;2(7):995-999. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17458843 17458843]
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==About this Structure==
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2P8H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8H OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:27:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:10:02 2008''

Revision as of 16:10, 20 March 2008

Image:2p8h.jpg


PDB ID 2p8h

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands:
Gene: BACE1, BACE (Homo sapiens)
Activity: Memapsin 2, with EC number 3.4.23.46
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human beta secretase complexed with inhibitor


About this Structure

2P8H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Mar 20 18:10:02 2008

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