4j5l

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==About this Structure==
==About this Structure==
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[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA].
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[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024097982</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024097982</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Assis, L H.P.]]
[[Category: Assis, L H.P.]]
[[Category: Berridge, G.]]
[[Category: Berridge, G.]]

Revision as of 12:37, 11 December 2013

Template:STRUCTURE 4j5l

Contents

Structure of the Cargo Binding Domain from Human Myosin Va

Template:ABSTRACT PUBMED 24097982

Disease

[MYO5A_HUMAN] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.[1]

About this Structure

4j5l is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Nascimento AF, Trindade DM, Tonoli CC, de Giuseppe PO, Assis LH, Honorato RV, de Oliveira PS, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT. Structural insights into functional overlapping and differentiation among myosin V motors. J Biol Chem. 2013 Oct 4. PMID:24097982 doi:http://dx.doi.org/10.1074/jbc.M113.507202
  1. ↑ Mehta AD, Rock RS, Rief M, Spudich JA, Mooseker MS, Cheney RE. Myosin-V is a processive actin-based motor. Nature. 1999 Aug 5;400(6744):590-3. PMID:10448864 doi:http://dx.doi.org/10.1038/23072

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