4cc3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4cc3" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4cc3| PDB=4cc3 | SCENE= }}
 +
===Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3===
-
The entry 4cc3 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/DNMBP_HUMAN DNMBP_HUMAN]] Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). [[http://www.uniprot.org/uniprot/ENAH_MOUSE ENAH_MOUSE]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.<ref>PMID:8861907</ref> <ref>PMID:10069337</ref> <ref>PMID:12134088</ref> <ref>PMID:15066263</ref>
-
Authors: Polle, L., Rigano, L., Julian, R., Ireton, K., Schubert, W.-D.
+
==About this Structure==
 +
[[4cc3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CC3 OCA].
-
Description: Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide -H3
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Ireton, K.]]
 +
[[Category: Julian, R.]]
 +
[[Category: Polle, L.]]
 +
[[Category: Rigano, L.]]
 +
[[Category: Schubert, W D.]]
 +
[[Category: Actin cytoskeleton]]
 +
[[Category: Cortical tension]]
 +
[[Category: Mena]]
 +
[[Category: Ndpp-1]]
 +
[[Category: Proline- rich peptide]]
 +
[[Category: Sh3 domain]]
 +
[[Category: Src homology 3]]
 +
[[Category: Structural protein]]
 +
[[Category: Tuba]]

Revision as of 09:48, 30 October 2013

Template:STRUCTURE 4cc3

Contents

Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3

Function

[DNMBP_HUMAN] Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). [ENAH_MOUSE] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.[1] [2] [3] [4]

About this Structure

4cc3 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Gertler FB, Niebuhr K, Reinhard M, Wehland J, Soriano P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39. PMID:8861907
  2. ↑ Lanier LM, Gates MA, Witke W, Menzies AS, Wehman AM, Macklis JD, Kwiatkowski D, Soriano P, Gertler FB. Mena is required for neurulation and commissure formation. Neuron. 1999 Feb;22(2):313-25. PMID:10069337
  3. ↑ Loureiro JJ, Rubinson DA, Bear JE, Baltus GA, Kwiatkowski AV, Gertler FB. Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell. 2002 Jul;13(7):2533-46. PMID:12134088 doi:http://dx.doi.org/10.1091/mbc.E01-10-0102
  4. ↑ Lebrand C, Dent EW, Strasser GA, Lanier LM, Krause M, Svitkina TM, Borisy GG, Gertler FB. Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron. 2004 Apr 8;42(1):37-49. PMID:15066263

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cc3"
Personal tools