4l6h

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'''Unreleased structure'''
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{{STRUCTURE_4l6h| PDB=4l6h | SCENE= }}
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===Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine===
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{{ABSTRACT_PUBMED_24524835}}
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The entry 4l6h is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
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Authors: Ubhi, D., Robertus, J.D.
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==About this Structure==
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[[4l6h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6H OCA].
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Description: Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine
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==Reference==
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<ref group="xtra">PMID:024524835</ref><references group="xtra"/><references/>
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[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
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[[Category: Robertus, J D.]]
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[[Category: Ubhi, D.]]
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[[Category: Cobalamin-independent]]
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[[Category: Dual tim barrel]]
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[[Category: Fungal]]
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[[Category: Methionine synthase]]
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[[Category: Surface entropy reduction]]
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[[Category: Transferase]]

Revision as of 04:24, 9 April 2014

Template:STRUCTURE 4l6h

Contents

Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine

Template:ABSTRACT PUBMED 24524835

Function

[METE_CANAL] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]

About this Structure

4l6h is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ubhi D, Kago G, Monzingo AF, Robertus JD. Structural analysis of a fungal methionine synthase with substrates and inhibitors. J Mol Biol. 2014 Apr 17;426(8):1839-47. doi: 10.1016/j.jmb.2014.02.006. Epub 2014, Feb 11. PMID:24524835 doi:http://dx.doi.org/10.1016/j.jmb.2014.02.006

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OCA

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