2pbi
From Proteopedia
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| - | [[Image:2pbi.jpg|left|200px]] | + | [[Image:2pbi.jpg|left|200px]] |
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| - | '''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure''' | + | {{Structure |
| + | |PDB= 2pbi |SIZE=350|CAPTION= <scene name='initialview01'>2pbi</scene>, resolution 1.950Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Residue+D+901'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+D+903'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Residue+A+904'>AC4</scene>, <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+905'>AC5</scene>, <scene name='pdbsite=AC6:Gol+Binding+Site+For+Residue+A+906'>AC6</scene>, <scene name='pdbsite=AC7:Gol+Binding+Site+For+Residue+C+907'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+D+908'>AC8</scene> and <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+909'>AC9</scene> | ||
| + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= Rgs9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Gnb5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PBI is a [ | + | 2PBI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBI OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:[http:// | + | Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18204463 18204463] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: signaling protein]] | [[Category: signaling protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:11:10 2008'' |
Revision as of 16:11, 20 March 2008
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| , resolution 1.950Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , and | ||||||
| Ligands: | |||||||
| Gene: | Rgs9 (Mus musculus), Gnb5 (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure
Overview
Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the atypical G protein beta5 (Gbeta5) subunit through an internal G protein gamma (Ggamma)-subunit-like (GGL) domain. Here we present the 1.95-A crystal structure of the Gbeta5-RGS9 complex, which is essential for normal visual and neuronal signal transduction. This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G-protein activation and deactivation.
About this Structure
2PBI is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:18204463
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