4jii
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | [[4jii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4jii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JII OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Chen, K.]] | [[Category: Chen, K.]] | ||
[[Category: Hu, X.]] | [[Category: Hu, X.]] | ||
Revision as of 08:47, 27 November 2013
Contents |
Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat
Template:ABSTRACT PUBMED 24100137
Function
[AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.[1]
About this Structure
4jii is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Zhang L, Zhang H, Zhao Y, Li Z, Chen S, Zhai J, Chen Y, Xie W, Wang Z, Li Q, Zheng X, Hu X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111). FEBS Lett. 2013 Oct 4. pii: S0014-5793(13)00726-6. doi:, 10.1016/j.febslet.2013.09.031. PMID:24100137 doi:http://dx.doi.org/10.1016/j.febslet.2013.09.031
