2pe6

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[[Image:2pe6.gif|left|200px]]<br /><applet load="2pe6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2pe6.gif|left|200px]]
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caption="2pe6, resolution 2.40&Aring;" />
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'''Non-covalent complex between human SUMO-1 and human Ubc9'''<br />
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{{Structure
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|PDB= 2pe6 |SIZE=350|CAPTION= <scene name='initialview01'>2pe6</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= UBE2I, UBC9, UBCE9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SUMO1, SMT3C, SMT3H3, UBL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Non-covalent complex between human SUMO-1 and human Ubc9'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2PE6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PE6 OCA].
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2PE6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PE6 OCA].
==Reference==
==Reference==
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Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction., Capili AD, Lima CD, J Mol Biol. 2007 Jun 8;369(3):608-18. Epub 2007 Apr 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17466333 17466333]
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Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction., Capili AD, Lima CD, J Mol Biol. 2007 Jun 8;369(3):608-18. Epub 2007 Apr 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17466333 17466333]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: ubiquitin-like]]
[[Category: ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:28:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:11:52 2008''

Revision as of 16:11, 20 March 2008

Image:2pe6.gif


PDB ID 2pe6

Drag the structure with the mouse to rotate
, resolution 2.40Å
Gene: UBE2I, UBC9, UBCE9 (Homo sapiens), SUMO1, SMT3C, SMT3H3, UBL1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Non-covalent complex between human SUMO-1 and human Ubc9


Contents

Overview

The SUMO E2 Ubc9 serves as a lynchpin in the SUMO conjugation pathway, interacting with the SUMO E1 during activation, with thioester linked SUMO after E1 transfer and with the substrate and SUMO E3 ligases during conjugation. Here, we describe the structure determination of a non-covalent complex between human Ubc9 and SUMO-1 at 2.4 A resolution. Non-covalent interactions between Ubc9 and SUMO are conserved in human and yeast insomuch as human Ubc9 interacts with each of the human SUMO isoforms, and yeast Ubc9 interacts with Smt3, the yeast SUMO ortholog. Structural comparisons reveal similarities to several other non-covalent complexes in the ubiquitin pathway, suggesting that the non-covalent Ubc9-SUMO interface may be important for poly-SUMO chain formation, for E2 recruitment to SUMO conjugated substrates, or for mediating E2 interactions with either E1 or E3 ligases. Biochemical analysis suggests that this surface is less important for E1 activation or di-SUMO-2 formation, but more important for E3 interactions and for poly-SUMO chain formation when the chain exceeds more than two SUMO proteins.

Disease

Known diseases associated with this structure: Orofacial cleft 10 OMIM:[601912]

About this Structure

2PE6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction., Capili AD, Lima CD, J Mol Biol. 2007 Jun 8;369(3):608-18. Epub 2007 Apr 6. PMID:17466333

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