2pdz
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2pdz.jpg|left|200px]] | + | [[Image:2pdz.jpg|left|200px]] |
| - | + | ||
| - | '''SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES''' | + | {{Structure |
| + | |PDB= 2pdz |SIZE=350|CAPTION= <scene name='initialview01'>2pdz</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2PDZ is a [ | + | 2PDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PDZ OCA]. |
==Reference== | ==Reference== | ||
| - | Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels., Schultz J, Hoffmuller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H, Nat Struct Biol. 1998 Jan;5(1):19-24. PMID:[http:// | + | Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels., Schultz J, Hoffmuller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H, Nat Struct Biol. 1998 Jan;5(1):19-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9437424 9437424] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 26: | Line 35: | ||
[[Category: voltage-gated sodium channel]] | [[Category: voltage-gated sodium channel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:11:49 2008'' |
Revision as of 16:11, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES
Overview
Syntrophins are modular proteins belonging to the dystrophin associated glycoprotein complex and are thought to be involved in the regulation of the muscular system. Screening of peptide libraries revealed selectivity of the synotrophin PDZ domain toward the motif R/K/Q-E-S/T-X-V-COO- found to be highly conserved in the alpha-subunit C-terminus of vertebrate voltage gated sodium channels (VGSCs). The solution structure of the domain in complex with the peptide G-V-K-E-S-L-V shows specific interactions between the conserved residues in the peptide and syntrophin-characteristic residues in the domain. We propose that syntrophins localize VGSCs to the dystrophin network through its PDZ domain.
About this Structure
2PDZ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels., Schultz J, Hoffmuller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H, Nat Struct Biol. 1998 Jan;5(1):19-24. PMID:9437424
Page seeded by OCA on Thu Mar 20 18:11:49 2008
