4mqb

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{{STRUCTURE_4mqb| PDB=4mqb | SCENE= }}
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==Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid==
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===Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid===
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<StructureSection load='4mqb' size='340' side='right' caption='[[4mqb]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mqb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eaq|4eaq]], [[4f4i|4f4i]], [[4dwj|4dwj]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, SAV0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 Staphylococcus aureus subsp. aureus Mu50])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mqb RCSB], [http://www.ebi.ac.uk/pdbsum/4mqb PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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*[[Thymidylate kinase|Thymidylate kinase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4mqb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQB OCA].
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[[Category: Staphylococcus aureus subsp. aureus mu50]]
[[Category: Staphylococcus aureus subsp. aureus mu50]]
[[Category: DTMP kinase]]
[[Category: DTMP kinase]]
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[[Category: Anderson, W F.]]
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[[Category: Anderson, W F]]
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[[Category: Babnigg, G.]]
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[[Category: Babnigg, G]]
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[[Category: Filippova, E V.]]
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[[Category: Filippova, E V]]
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[[Category: Jedrzejczak, R.]]
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[[Category: Jedrzejczak, R]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak, A]]
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[[Category: Kiryukhina, O.]]
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[[Category: Kiryukhina, O]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Structural genomic]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
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[[Category: Minasov, G.]]
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[[Category: Minasov, G]]
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[[Category: Rubin, E.]]
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[[Category: Rubin, E]]
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[[Category: Sacchettini, J.]]
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[[Category: Sacchettini, J]]
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[[Category: Shuvalova, L.]]
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[[Category: Shuvalova, L]]
[[Category: Mcsg]]
[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
 
[[Category: Mtb proteins conferring susceptibility to known mtb inhibitor]]
[[Category: Mtb proteins conferring susceptibility to known mtb inhibitor]]
[[Category: Mtbi]]
[[Category: Mtbi]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
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[[Category: Structural genomic]]
 
[[Category: Thymidylate kinase]]
[[Category: Thymidylate kinase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 15:09, 21 December 2014

Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid

4mqb, resolution 1.55Å

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