3ke1

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{{STRUCTURE_3ke1| PDB=3ke1 | SCENE= }}
{{STRUCTURE_3ke1| PDB=3ke1 | SCENE= }}
===Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with a fragment-nucleoside fusion D000161829===
===Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with a fragment-nucleoside fusion D000161829===
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{{ABSTRACT_PUBMED_23382856}}
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{{ABSTRACT_PUBMED_24157367}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[3ke1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KE1 OCA].
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[[3ke1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KE1 OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:023382856</ref><references group="xtra"/><references/>
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<ref group="xtra">PMID:024157367</ref><references group="xtra"/><references/>
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[[Category: Bacillus pseudomallei whitmore 1913]]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
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[[Category: Burkholderia pseudomallei]]
 
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: D000161829]]
[[Category: D000161829]]

Revision as of 12:28, 11 December 2013

Template:STRUCTURE 3ke1

Contents

Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with a fragment-nucleoside fusion D000161829

Template:ABSTRACT PUBMED 24157367

Function

[ISPF_BURPS] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]

About this Structure

3ke1 is a 3 chain structure with sequence from "bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913. Full crystallographic information is available from OCA.

See Also

Reference

  • Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6860-3. doi: 10.1016/j.bmcl.2013.09.101., Epub 2013 Oct 8. PMID:24157367 doi:http://dx.doi.org/10.1016/j.bmcl.2013.09.101

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