4kp7

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==About this Structure==
==About this Structure==
-
[[4kp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_hb3 Plasmodium falciparum hb3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP7 OCA].
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[[4kp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafx Plafx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP7 OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024032981</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024032981</ref><references group="xtra"/><references/>
[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
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[[Category: Plasmodium falciparum hb3]]
+
[[Category: Plafx]]
[[Category: Bacher, A.]]
[[Category: Bacher, A.]]
[[Category: Groll, M.]]
[[Category: Groll, M.]]

Revision as of 04:04, 13 February 2014

Template:STRUCTURE 4kp7

Contents

Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin

Template:ABSTRACT PUBMED 24032981

Function

[DXR_PLAFX] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[1]

About this Structure

4kp7 is a 2 chain structure with sequence from Plafx. Full crystallographic information is available from OCA.

Reference

  • Kunfermann A, Lienau C, Illarionov B, Held J, Grawert T, Behrendt CT, Werner P, Hahn S, Eisenreich W, Riederer U, Mordmuller B, Bacher A, Fischer M, Groll M, Kurz T. IspC as target for antiinfective drug discovery: Synthesis, enantiomeric separation and structural biology of fosmidomycin thia-isosters. J Med Chem. 2013 Sep 13. PMID:24032981 doi:10.1021/jm4012559
  1. ↑ Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Turbachova I, Eberl M, Zeidler J, Lichtenthaler HK, Soldati D, Beck E. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6. PMID:10477522

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