4jlw

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{{STRUCTURE_4jlw| PDB=4jlw | SCENE= }}
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==Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa==
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===Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa===
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<StructureSection load='4jlw' size='340' side='right' caption='[[4jlw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23989142}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jlw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_lesb58 Pseudomonas aeruginosa lesb58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JLW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fdhA, PLES_58161 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=557722 Pseudomonas aeruginosa LESB58])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jlw RCSB], [http://www.ebi.ac.uk/pdbsum/4jlw PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Formaldehyde dehydrogenase (FDH) is a member of the zinc-containing medium-chain alcohol dehydrogenase family which oxidizes toxic formaldehyde to formate using NAD(+) as an electron carrier. Three-dimensional structures have been reported for FDHs from several different species. Most FDHs are dependent on glutathione for catalysis, but the enzyme from Pseudomonas putida is an exception. In this structural communication, the recombinant production, crystallization and X-ray structure determination at 2.7 A resolution of FDH from P. aeruginosa are described. Both the tetrameric assembly and the NAD(+)-binding mode of P. aeruginosa FDH are similar to those of P. putida FDH, which is in good agreement with the high sequence identity (87.97%) between these two proteins. Preliminary enzymatic kinetics studies of P. aeruginosa FDH also revealed a conserved glutathione-independent `ping-pong' mechanism of formaldehyde oxidization.
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==About this Structure==
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Structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa: the binary complex with the cofactor NAD+.,Liao Y, Chen S, Wang D, Zhang W, Wang S, Ding J, Wang Y, Cai L, Ran X, Wang X, Zhu H Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):967-72. doi: , 10.1107/S174430911302160X. Epub 2013 Aug 19. PMID:23989142<ref>PMID:23989142</ref>
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[[4jlw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_lesb58 Pseudomonas aeruginosa lesb58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLW OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023989142</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Pseudomonas aeruginosa lesb58]]
[[Category: Pseudomonas aeruginosa lesb58]]
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[[Category: Cai, L J.]]
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[[Category: Cai, L J]]
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[[Category: Chen, S.]]
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[[Category: Chen, S]]
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[[Category: Ding, J F.]]
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[[Category: Ding, J F]]
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[[Category: Liao, Y P.]]
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[[Category: Liao, Y P]]
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[[Category: Ran, X Y.]]
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[[Category: Ran, X Y]]
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[[Category: Wang, D L.]]
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[[Category: Wang, D L]]
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[[Category: Wang, S.]]
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[[Category: Wang, S]]
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[[Category: Wang, Y M.]]
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[[Category: Wang, Y M]]
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[[Category: Zhu, H X.]]
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[[Category: Zhu, H X]]
[[Category: Dehydrogenase]]
[[Category: Dehydrogenase]]
[[Category: Nad+ binding]]
[[Category: Nad+ binding]]

Revision as of 15:13, 21 December 2014

Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa

4jlw, resolution 2.70Å

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