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4hvy

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4hvy| PDB=4hvy | SCENE= }}
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===A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration===
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{{ABSTRACT_PUBMED_24352381}}
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The entry 4hvy is ON HOLD until Feb 06 2015
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==Function==
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[[http://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN]] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
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Authors: Asial, I., Cheng, Y.X., Engman, H., Wu, B., Dollhopf, M., Nordlund, P., Cornvik, T.
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==About this Structure==
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[[4hvy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVY OCA].
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Description: A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration
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==Reference==
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<ref group="xtra">PMID:024352381</ref><references group="xtra"/><references/>
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[[Category: Asial, I.]]
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[[Category: Cheng, Y X.]]
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[[Category: Cornvik, T.]]
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[[Category: Dollhopf, M.]]
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[[Category: Engman, H.]]
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[[Category: Nordlund, P.]]
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[[Category: Wu, B.]]
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[[Category: Directed evolution]]
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[[Category: Hot colony filtration]]
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[[Category: Hot-cofi]]
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[[Category: Hydrolase]]
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[[Category: Thermostability]]

Revision as of 12:06, 1 January 2014

Template:STRUCTURE 4hvy

Contents

A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration

Template:ABSTRACT PUBMED 24352381

Function

[NUD18_HUMAN] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

About this Structure

4hvy is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Asial I, Cheng YX, Engman H, Dollhopf M, Wu B, Nordlund P, Cornvik T. Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell. Nat Commun. 2013 Dec 19;4:2901. doi: 10.1038/ncomms3901. PMID:24352381 doi:http://dx.doi.org/10.1038/ncomms3901

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OCA

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