2pqw
From Proteopedia
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| - | [[Image:2pqw.jpg|left|200px]] | + | [[Image:2pqw.jpg|left|200px]] |
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| - | '''Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form''' | + | {{Structure |
| + | |PDB= 2pqw |SIZE=350|CAPTION= <scene name='initialview01'>2pqw</scene>, resolution 2.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PQW is a [ | + | 2PQW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQW OCA]. |
==Reference== | ==Reference== | ||
| - | L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:[http:// | + | L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18026117 18026117] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: l(3)mbt-like protein]] | [[Category: l(3)mbt-like protein]] | ||
[[Category: sgc]] | [[Category: sgc]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural genomics consortium]] | [[Category: structural genomics consortium]] | ||
[[Category: transcription]] | [[Category: transcription]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:16:21 2008'' |
Revision as of 16:16, 20 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | L3MBTL, KIAA0681, L3MBT (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form
Overview
Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.
About this Structure
2PQW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117
Page seeded by OCA on Thu Mar 20 18:16:21 2008
Categories: Homo sapiens | Single protein | Allali-Hassani, A. | Arrowsmith, C H. | Bochkarev, A. | Crombet, L. | Edwards, A M. | Herzanych, N. | Kozieradzki, I. | Liu, Y. | Loppnau, P. | Mackenzie, F. | Min, J R. | Ouyang, H. | SGC, Structural Genomics Consortium. | Sundstrom, M. | Vedadi, M. | Weigelt, J. | ACT | L(3)mbt-like protein | Sgc | Structural genomic | Structural genomics consortium | Transcription
