4m7h

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'''Unreleased structure'''
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{{STRUCTURE_4m7h| PDB=4m7h | SCENE= }}
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===Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1===
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The entry 4m7h is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FBCD1_HUMAN FBCD1_HUMAN]] Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.<ref>PMID:19710473</ref> <ref>PMID:19892701</ref>
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Authors: Shrive, A.K., Greenhough, T.J., Holmskov, U.
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==About this Structure==
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[[4m7h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7H OCA].
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Description: Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Greenhough, T J.]]
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[[Category: Holmskov, U.]]
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[[Category: Shrive, A K.]]
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[[Category: Carbohydrate/sugar binding]]
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[[Category: Fibrinogen-like domain]]
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[[Category: N-acetyl-binding protein]]
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[[Category: Putative chitin receptor]]
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[[Category: Sugar binding protein]]

Revision as of 13:50, 11 December 2013

Template:STRUCTURE 4m7h

Contents

Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1

Function

[FBCD1_HUMAN] Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.[1] [2]

About this Structure

4m7h is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Schlosser A, Thomsen T, Moeller JB, Nielsen O, Tornoe I, Mollenhauer J, Moestrup SK, Holmskov U. Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. J Immunol. 2009 Sep 15;183(6):3800-9. doi: 10.4049/jimmunol.0901526. Epub 2009, Aug 26. PMID:19710473 doi:http://dx.doi.org/10.4049/jimmunol.0901526
  2. ↑ Thomsen T, Moeller JB, Schlosser A, Sorensen GL, Moestrup SK, Palaniyar N, Wallis R, Mollenhauer J, Holmskov U. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem. 2010 Jan 8;285(2):1229-38. doi: 10.1074/jbc.M109.061523. Epub 2009, Nov 5. PMID:19892701 doi:http://dx.doi.org/10.1074/jbc.M109.061523

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