4m8g

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-	'''Unreleased structure'''	+	{{STRUCTURE_4m8g| PDB=4m8g | SCENE= }}
		+	===Crystal structure of Se-Met hN33/Tusc3===
-	The entry 4m8g is ON HOLD until Paper Publication	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TUSC3_HUMAN TUSC3_HUMAN]] Autosomal recessive nonsyndromic intellectual deficit. The disease is caused by mutations affecting the gene represented in this entry.
-	Authors: Mohorko, E., Owen, R.L., Malojcic, G., Brozzo, M.S., Aebi, M., Glockshuber, R.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TUSC3_HUMAN TUSC3_HUMAN]] Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.<ref>PMID:19717468</ref>
-	Description: Crystal structure of Se-Met hN33/Tusc3	+	==About this Structure==
		+	[[4m8g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8G OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Aebi, M.]]
		+	[[Category: Brozzo, M S.]]
		+	[[Category: Glockshuber, R.]]
		+	[[Category: Malojcic, G.]]
		+	[[Category: Mohorko, E.]]
		+	[[Category: Owen, R L.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Redox-active protein]]
		+	[[Category: Thiol/disulfide exchange reaction]]
		+	[[Category: Thiol/disulfide oxidoreductase]]
		+	[[Category: Thioredoxin-like fold]]

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Revision as of 09:34, 26 March 2014

Template:STRUCTURE 4m8g

Contents 1 Crystal structure of Se-Met hN33/Tusc3 2 Disease 3 Function 4 About this Structure 5 Reference

Crystal structure of Se-Met hN33/Tusc3

Disease

[TUSC3_HUMAN] Autosomal recessive nonsyndromic intellectual deficit. The disease is caused by mutations affecting the gene represented in this entry.

Function

[TUSC3_HUMAN] Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl transferase.^[1]

About this Structure

4m8g is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15750-5. Epub 2009 Aug 26. PMID:19717468 doi:http://dx.doi.org/0908332106