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4nac

From Proteopedia

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m (Protected "4nac" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4nac| PDB=4nac | SCENE= }}
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===Crystal Structure of the N-terminal Domain of p15RS===
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The entry 4nac is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref>
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Authors: Mei, K., Jin, Z., Ren, F., Wang, Y.
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==About this Structure==
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[[4nac]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAC OCA].
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Description: Crystal Structure of the N-terminal Domain of p15RS
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Jin, Z.]]
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[[Category: Mei, K.]]
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[[Category: Ren, F.]]
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[[Category: Wang, Y.]]
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[[Category: Alpha helix]]
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[[Category: Transcription]]

Revision as of 13:53, 11 December 2013

Template:STRUCTURE 4nac

Contents

Crystal Structure of the N-terminal Domain of p15RS

Function

[RPR1A_HUMAN] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.[1] [2]

About this Structure

4nac is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Liu J, Liu H, Zhang X, Gao P, Wang J, Hu Z. Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression. Biochem Biophys Res Commun. 2002 Dec 20;299(5):880-5. PMID:12470661
  2. ↑ Ni Z, Olsen JB, Guo X, Zhong G, Ruan ED, Marcon E, Young P, Guo H, Li J, Moffat J, Emili A, Greenblatt JF. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription. 2011 Sep-Oct;2(5):237-42. doi: 10.4161/trns.2.5.17803. PMID:22231121 doi:http://dx.doi.org/10.4161/trns.2.5.17803

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