4nb6

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m (Protected "4nb6" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4nb6| PDB=4nb6 | SCENE= }}
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===Crystal structure of the ligand binding domain of RORC with T0901317===
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The entry 4nb6 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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Authors: Hymowitz, S.G., Boenig-de Leon, G.
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==About this Structure==
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[[4nb6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB6 OCA].
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Description: Crystal structure of the ligand binding domain of RORC with T0901317
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[[Category: Hymowitz, S G.]]
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[[Category: Leon, G Boenig-de.]]
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[[Category: Alpha-helical]]
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[[Category: Nucleus]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]

Revision as of 10:37, 27 November 2013

Template:STRUCTURE 4nb6

Crystal structure of the ligand binding domain of RORC with T0901317

Function

[RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

About this Structure

4nb6 is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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