4c40
From Proteopedia
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| - | + | ==The molecular recognition of kink turn structure by the L7Ae class of proteins== | |
| - | + | <StructureSection load='4c40' size='340' side='right' caption='[[4c40]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4c40]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C40 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw0|4bw0]], [[4c4w|4c4w]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c40 RCSB], [http://www.ebi.ac.uk/pdbsum/4c40 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | L7Ae is a member of a protein family that binds kink-turns (k-turns) in many functional RNA species. We have solved the X-ray crystal structure of the near-consensus sequence Kt-7 of Haloarcula marismortui bound by Archaeoglobus fulgidus L7Ae at 2.3-A resolution. We also present a structure of Kt-7 in the absence of bound protein at 2.2-A resolution. As a result, we can describe a general mode of recognition of k-turn structure by the L7Ae family proteins. The protein makes interactions in the widened major groove on the outer face of the k-turn. Two regions of the protein are involved. One is an alpha-helix that enters the major groove of the NC helix, making both nonspecific backbone interactions and specific interactions with the guanine nucleobases of the conserved G*A pairs. A hydrophobic loop makes close contact with the L1 and L2 bases, and a glutamate side chain hydrogen bonds with L1. Taken together, these interactions are highly selective for the structure of the k-turn and suggest how conformational selection of the folded k-turn occurs. | ||
| - | + | The molecular recognition of kink-turn structure by the L7Ae class of proteins.,Huang L, Lilley DM RNA. 2013 Oct 22. PMID:24149842<ref>PMID:24149842</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Huang, L | + | == References == |
| - | [[Category: Lilley, D M.J | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Huang, L]] | ||
| + | [[Category: Lilley, D M.J]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Kink turn]] | [[Category: Kink turn]] | ||
[[Category: Rna]] | [[Category: Rna]] | ||
Revision as of 09:37, 21 December 2014
The molecular recognition of kink turn structure by the L7Ae class of proteins
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Categories: Huang, L | Lilley, D M.J | Dna | Kink turn | Rna
