1x22
From Proteopedia
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| - | + | ==Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura== | |
| - | + | <StructureSection load='1x22' size='340' side='right' caption='[[1x22]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1x22]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X22 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x22 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x22 RCSB], [http://www.ebi.ac.uk/pdbsum/1x22 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An antibacterial peptide was isolated from a lepidopteran insect, Spodoptera litura. The molecular mass of this peptide was determined to be 4489.55 by matrix assisted laser desorption/ionization-time of flight mass (MALDI-TOF MS) spectrometry. The peptide consists of 42 amino acids and the sequence has 69-98% identity to those of moricin-related peptides, antibacterial peptides from lepidopetran insects. Thus, the peptide was designated S. litura (Sl) moricin. Sl moricin showed a broad antibacterial spectrum against Gram-positive and negative bacteria. Sl moricin gene was inducible by bacterial injection and expressed tissue-specifically in the fat body and hemocytes. Furthermore, the solution structure of Sl moricin was determined by two-dimensional (2D) 1H-nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-simulated annealing calculation. The tertiary structure revealed a long alpha-helix containing eight turns along nearly the full length of the peptide like that of moricin, confirming that Sl moricin is a new moricin-like antibacterial peptide. These results suggest that moricin is present not only in B. mori but also in other lepidopteran insects forming a gene family. | ||
| - | + | Isolation, gene expression and solution structure of a novel moricin analogue, antibacterial peptide from a lepidopteran insect, Spodoptera litura.,Oizumi Y, Hemmi H, Minami M, Asaoka A, Yamakawa M Biochim Biophys Acta. 2005 Aug 31;1752(1):83-92. PMID:16115804<ref>PMID:16115804</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Asaoka, A | + | == References == |
| - | [[Category: Hemmi, H | + | <references/> |
| - | [[Category: Minami, M | + | __TOC__ |
| - | [[Category: Oizumi, Y | + | </StructureSection> |
| - | [[Category: Yamakawa, M | + | [[Category: Asaoka, A]] |
| + | [[Category: Hemmi, H]] | ||
| + | [[Category: Minami, M]] | ||
| + | [[Category: Oizumi, Y]] | ||
| + | [[Category: Yamakawa, M]] | ||
[[Category: Antibacterial peptide]] | [[Category: Antibacterial peptide]] | ||
[[Category: Antibiotic]] | [[Category: Antibiotic]] | ||
Revision as of 11:59, 18 December 2014
Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura
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