2pyr
From Proteopedia
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| - | [[Image:2pyr.jpg|left|200px]] | + | [[Image:2pyr.jpg|left|200px]] |
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| - | '''PHOTOACTIVE YELLOW PROTEIN, 1 NANOSECOND INTERMEDIATE (287K)''' | + | {{Structure |
| + | |PDB= 2pyr |SIZE=350|CAPTION= <scene name='initialview01'>2pyr</scene>, resolution 1.9Å | ||
| + | |SITE= <scene name='pdbsite=CRE:The+Chromophore+Is+Linked+To+The+Peptide+By+A+Thioester+...'>CRE</scene> | ||
| + | |LIGAND= <scene name='pdbligand=HC4:4'-HYDROXYCINNAMIC ACID'>HC4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= P16113 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1053 Halorhodospira halophila]) | ||
| + | }} | ||
| + | |||
| + | '''PHOTOACTIVE YELLOW PROTEIN, 1 NANOSECOND INTERMEDIATE (287K)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PYR is a [ | + | 2PYR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYR OCA]. |
==Reference== | ==Reference== | ||
| - | Energy transduction on the nanosecond time scale: early structural events in a xanthopsin photocycle., Perman B, Srajer V, Ren Z, Teng T, Pradervand C, Ursby T, Bourgeois D, Schotte F, Wulff M, Kort R, Hellingwerf K, Moffat K, Science. 1998 Mar 20;279(5358):1946-50. PMID:[http:// | + | Energy transduction on the nanosecond time scale: early structural events in a xanthopsin photocycle., Perman B, Srajer V, Ren Z, Teng T, Pradervand C, Ursby T, Bourgeois D, Schotte F, Wulff M, Kort R, Hellingwerf K, Moffat K, Science. 1998 Mar 20;279(5358):1946-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9506946 9506946] |
[[Category: Halorhodospira halophila]] | [[Category: Halorhodospira halophila]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: photoreceptor]] | [[Category: photoreceptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:19:38 2008'' |
Revision as of 16:19, 20 March 2008
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| , resolution 1.9Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Gene: | P16113 (Halorhodospira halophila) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PHOTOACTIVE YELLOW PROTEIN, 1 NANOSECOND INTERMEDIATE (287K)
Overview
Photoactive yellow protein (PYP) is a member of the xanthopsin family of eubacterial blue-light photoreceptors. On absorption of light, PYP enters a photocycle that ultimately transduces the energy contained in a light signal into an altered biological response. Nanosecond time-resolved x-ray crystallography was used to determine the structure of the short-lived, red-shifted, intermediate state denoted [pR], which develops within 1 nanosecond after photoelectronic excitation of the chromophore of PYP by absorption of light. The resulting structural model demonstrates that the [pR] state possesses the cis conformation of the 4-hydroxyl cinnamic thioester chromophore, and that the process of trans to cis isomerization is accompanied by the specific formation of new hydrogen bonds that replace those broken upon excitation of the chromophore. Regions of flexibility that compose the chromophore-binding pocket serve to lower the activation energy barrier between the dark state, denoted pG, and [pR], and help initiate entrance into the photocycle. Direct structural evidence is provided for the initial processes of transduction of light energy, which ultimately translate into a physiological signal.
About this Structure
2PYR is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.
Reference
Energy transduction on the nanosecond time scale: early structural events in a xanthopsin photocycle., Perman B, Srajer V, Ren Z, Teng T, Pradervand C, Ursby T, Bourgeois D, Schotte F, Wulff M, Kort R, Hellingwerf K, Moffat K, Science. 1998 Mar 20;279(5358):1946-50. PMID:9506946
Page seeded by OCA on Thu Mar 20 18:19:38 2008
