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2mcu

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'''Unreleased structure'''
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{{STRUCTURE_2mcu| PDB=2mcu | SCENE= }}
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===Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers===
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The entry 2mcu is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MORO_MORSA MORO_MORSA]] Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores.<ref>PMID:11713517</ref> <ref>PMID:17253775</ref>
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Authors: Fu, R., Tian, Y., Perrin Jr., B.S., Grant, C.V., Pastor, R.W., Cotten, M.L.
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==About this Structure==
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[[2mcu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCU OCA].
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Description: Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Cotten, M L.]]
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[[Category: Fu, R.]]
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[[Category: Grant, C V.]]
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[[Category: Pastor, R W.]]
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[[Category: Perrin, B S.]]
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[[Category: Tian, Y.]]
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[[Category: Amphipathic]]
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[[Category: Anti hiv-1]]
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[[Category: Anticancer peptide]]
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[[Category: Antimicrobial peptide]]
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[[Category: Antimicrobial protein]]
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[[Category: Bacterial cell membrane mimic]]
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[[Category: Cationic]]
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[[Category: Helical]]
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[[Category: Histidine rich]]
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[[Category: Lipid bilayer]]

Revision as of 06:59, 22 January 2014

Template:STRUCTURE 2mcu

Contents

Solid-state NMR structure of piscidin 1 in aligned 3:1 phosphatidylcholine/phosphoglycerol lipid bilayers

Function

[MORO_MORSA] Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores.[1] [2]

About this Structure

2mcu is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Silphaduang U, Noga EJ. Peptide antibiotics in mast cells of fish. Nature. 2001 Nov 15;414(6861):268-9. PMID:11713517 doi:http://dx.doi.org/10.1038/35104690
  2. ↑ Campagna S, Saint N, Molle G, Aumelas A. Structure and mechanism of action of the antimicrobial peptide piscidin. Biochemistry. 2007 Feb 20;46(7):1771-8. Epub 2007 Jan 25. PMID:17253775 doi:10.1021/bi0620297

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OCA

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