4bkm

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'''Unreleased structure'''
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{{STRUCTURE_4bkm| PDB=4bkm | SCENE= }}
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===Crystal structure of the murine AUM (phosphoglycolate phosphatase) capping domain as a fusion protein with the catalytic core domain of murine chronophin (pyridoxal phosphate phosphatase)===
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{{ABSTRACT_PUBMED_24338473}}
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The entry 4bkm is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PLPP_MOUSE PLPP_MOUSE]] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity).
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Authors: Knobloch, G., Seifried, A., Gohla, A., Schindelin, H.
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==About this Structure==
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[[4bkm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKM OCA].
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Description: Crystal structure of the murine AUM (phosphoglycolate phosphatase) capping domain as a fusion protein with the catalytic core domain of murine chronophin (pyridoxal phosphate phosphatase)
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==Reference==
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<ref group="xtra">PMID:024338473</ref><references group="xtra"/><references/>
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[[Category: Gohla, A.]]
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[[Category: Knobloch, G.]]
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[[Category: Schindelin, H.]]
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[[Category: Seifried, A.]]
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[[Category: Had family]]
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[[Category: Hydrolase]]

Revision as of 10:15, 25 December 2013

Template:STRUCTURE 4bkm

Contents

Crystal structure of the murine AUM (phosphoglycolate phosphatase) capping domain as a fusion protein with the catalytic core domain of murine chronophin (pyridoxal phosphate phosphatase)

Template:ABSTRACT PUBMED 24338473

Function

[PLPP_MOUSE] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity).

About this Structure

4bkm is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Seifried A, Knobloch G, Duraphe PS, Segerer G, Manhard J, Schindelin H, Schultz J, Gohla A. Evolutionary and Structural Analyses of the Mammalian Haloacid Dehalogenase-Type Phosphatases AUM and Chronophin Provide Insight into the Basis of their Different Substrate Specificities. J Biol Chem. 2013 Dec 13. PMID:24338473 doi:http://dx.doi.org/10.1074/jbc.M113.503359

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OCA

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