4n7m

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-	'''Unreleased structure'''	+	{{STRUCTURE_4n7m| PDB=4n7m | SCENE= }}
		+	===Tailoring Small Molecules for an Allosteric Site on Procaspase-6===
		+	{{ABSTRACT_PUBMED_24259468}}
-	The entry 4n7m is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
-	Authors: Murray, J.M., Steffek, M	+	==About this Structure==
		+	[[4n7m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7M OCA].
-	Description: Tailoring Small Molecules for an Allosteric Site on Procaspase-6	+	==Reference==
		+	<ref group="xtra">PMID:024259468</ref><references group="xtra"/><references/>
		+	[[Category: Caspase-6]]
		+	[[Category: Murray, J M.]]
		+	[[Category: Steffek, M]]
		+	[[Category: Allosteric]]
		+	[[Category: Caspase-6 zymogen]]
		+	[[Category: Cysteine protease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Procaspse-6]]
		+	[[Category: Structure based drug design]]

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Revision as of 10:18, 18 December 2013

Template:STRUCTURE 4n7m

Contents 1 Tailoring Small Molecules for an Allosteric Site on Procaspase-6 2 Function 3 About this Structure 4 Reference

Tailoring Small Molecules for an Allosteric Site on Procaspase-6

Template:ABSTRACT PUBMED 24259468

Function

[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

About this Structure

4n7m is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring Small Molecules for an Allosteric Site on Procaspase-6. ChemMedChem. 2013 Nov 20. doi: 10.1002/cmdc.201300424. PMID:24259468 doi:http://dx.doi.org/10.1002/cmdc.201300424