4hmn

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{{STRUCTURE_4hmn| PDB=4hmn | SCENE= }}
{{STRUCTURE_4hmn| PDB=4hmn | SCENE= }}
===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)===
===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)===
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{{ABSTRACT_PUBMED_24411201}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4hmn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA].
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[[4hmn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA].
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==Reference==
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<ref group="xtra">PMID:024411201</ref><references group="xtra"/><references/>
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[[Category: Human]]
[[Category: Atwell, G J.]]
[[Category: Atwell, G J.]]
[[Category: Brooke, D G.]]
[[Category: Brooke, D G.]]

Revision as of 14:35, 3 March 2014

Template:STRUCTURE 4hmn

Contents

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)

Template:ABSTRACT PUBMED 24411201

Function

[AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

About this Structure

4hmn is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Flanagan JU, Atwell GJ, Heinrich DM, Brooke DG, Silva S, Rigoreau LJ, Trivier E, Turnbull AP, Raynham T, Jamieson SM, Denny WA. Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-beta-hydroxysteroid dehydrogenase (AKR1C3). Bioorg Med Chem. 2014 Feb 1;22(3):967-77. doi: 10.1016/j.bmc.2013.12.050. Epub, 2014 Jan 2. PMID:24411201 doi:http://dx.doi.org/10.1016/j.bmc.2013.12.050

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