4mxv
From Proteopedia
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{{STRUCTURE_4mxv| PDB=4mxv | SCENE= }} | {{STRUCTURE_4mxv| PDB=4mxv | SCENE= }} | ||
===Structure of Lymphotoxin alpha bound to anti-LTa Fab=== | ===Structure of Lymphotoxin alpha bound to anti-LTa Fab=== | ||
| + | {{ABSTRACT_PUBMED_24248355}} | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4mxv]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXV OCA]. | + | [[4mxv]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXV OCA]. |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024248355</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Hymowitz, S G.]] | [[Category: Hymowitz, S G.]] | ||
[[Category: Yin, J P.]] | [[Category: Yin, J P.]] | ||
Revision as of 12:13, 11 December 2013
Contents |
Structure of Lymphotoxin alpha bound to anti-LTa Fab
Template:ABSTRACT PUBMED 24248355
Disease
[TNFB_HUMAN] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Function
[TNFB_HUMAN] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
About this Structure
4mxv is a 9 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Sudhamsu J, Yin J, Chiang EY, Starovasnik MA, Grogan JL, Hymowitz SG. Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19896-901. doi:, 10.1073/pnas.1310838110. Epub 2013 Nov 18. PMID:24248355 doi:http://dx.doi.org/10.1073/pnas.1310838110
