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Dihydropteroate synthase
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[[2bmb]] - PPPK-DHPS + pterin-methyl-phosphate - yeast | [[2bmb]] - PPPK-DHPS + pterin-methyl-phosphate - yeast | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:18, 13 November 2013
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3S structures of dihydropteroate synthase
Updated on 13-November-2013
1ad1 – SaDHPS - Staphylococcus aureus
1ajz – EcDHPS – Escherichia coli
1tws, 3v5o – BaDHPS – Bacillus anthracis
2dqw - TtDHPS – Thermus thermophilus
2vef - SpDHPS – Streptococcus pneumonia
2vp8 – MtDHPS – Mycobacterium tuberculosis
2y5j – BcDHPS – Burkholderia cenocepacia
3tzn – YpDHPS – Yersinia pestis
DHPS binary comlexes
1ad4 – SaDHPS + pterin-pyrophosphate
1aj2 – EcDHPS + dihydro-pterin-methanyl-phosphonophosphate
1eye - MtDHPS + pterin-methyl-phosphate
1tww - BaDHPS + hydroxymethylpterin-diphosphate
1twz - BaDHPS + pterin-methyl-phosphate
1tx0 - BaDHPS + pteroic acid
1tx2, 3h21, 3h22, 3h23, 3h24, 3h26, 3h2a, 3h2c, 3h2e, 3h2f, 3h2m, 3h2n, 3h2o, 4d8z, 4d9p, 4dai, 4db7, 4d8a, 4daf - BaDHPS + inhibitor
2dza - TtDHPS + PABA
2dzb - TtDHPS + hydroxymethylpterin-diphosphate
2veg - SpDHPS + pterin-methyl-phosphate
2y5s - BcDHPS + dihydro-pteroate
3tya - BaDHPS + dihydro-pteroate
3tyc - BaDHPS + amino-hydroxymethyl-dihydro-pteridinone
3tr9 - DHPS + pteroic acid – Coxiella burnetii
3tyu – YpDHPS + pteroic acid
DHPS ternary complexes
1aj0 – EcDHPS + sulfanilamide + amino-methyldiene-dihydro-pteridinone
3tyb - BaDHPS + hydroxybenzoic acid + amino-hydroxymethyl-dihydro-pteridinone
3tyd - BaDHPS + pyrophosphate+ amino-hydroxymethyl-dihydro-pteridinone
3tye - BaDHPS + sulfa derivative + amino-hydroxymethyl-dihydro-pteridinone
3tyz - YpDHPS + pyrophosphate + PABA + amino-hydroxymethyl-dihydro-pteridinone
3tzf - YpDHPS + sulfa derivative + hydroxymethylpterin-diphosphate
Bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophsphokinase-DHPS
3mcm, 3mcn – FtPPPK-DHPS – Francisella tulerensis
3mco - FtPPPK-DHPS + amino-hydroxymethyl-dihydro-pteridinone + methyladenosine triphosphate
2bmb - PPPK-DHPS + pterin-methyl-phosphate - yeast
References
- ↑ Chu WT, Zhang JL, Zheng QC, Chen L, Xue Q, Zhang HX. Insights into the drug resistance induced by the BaDHPS mutations: molecular dynamic simulations and MM/GBSA studies. J Biomol Struct Dyn. 2012 Oct 2. PMID:23030549 doi:10.1080/07391102.2012.726529
