4bza
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of TamA POTRA domains 1-3 from E. coli== | |
| - | + | <StructureSection load='4bza' size='340' side='right' caption='[[4bza]], [[Resolution|resolution]] 1.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4bza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BZA FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c00|4c00]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bza RCSB], [http://www.ebi.ac.uk/pdbsum/4bza PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/TAMA_ECOLI TAMA_ECOLI]] Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear.<ref>PMID:22466966</ref> | [[http://www.uniprot.org/uniprot/TAMA_ECOLI TAMA_ECOLI]] Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear.<ref>PMID:22466966</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | TamA is an Escherichia coli Omp85 protein involved in autotransporter biogenesis. It comprises a 16-stranded transmembrane beta-barrel and three POTRA domains. The 2.3-A crystal structure reveals that the TamA barrel is closed at the extracellular face by a conserved lid loop. The C-terminal beta-strand of the barrel forms an unusual inward kink, which weakens the lateral barrel wall and creates a gate for substrate access to the lipid bilayer. | ||
| - | + | The structural basis of autotransporter translocation by TamA.,Gruss F, Zahringer F, Jakob RP, Burmann BM, Hiller S, Maier T Nat Struct Mol Biol. 2013 Sep 22. doi: 10.1038/nsmb.2689. PMID:24056943<ref>PMID:24056943</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ecobd]] | [[Category: Ecobd]] | ||
| - | [[Category: Burmann, B M | + | [[Category: Burmann, B M]] |
| - | [[Category: Gruss, F | + | [[Category: Gruss, F]] |
| - | [[Category: Hiller, S | + | [[Category: Hiller, S]] |
| - | [[Category: Jakob, R P | + | [[Category: Jakob, R P]] |
| - | [[Category: Maier, T | + | [[Category: Maier, T]] |
| - | [[Category: Zaehringer, F | + | [[Category: Zaehringer, F]] |
[[Category: Autotransporter biogenesis]] | [[Category: Autotransporter biogenesis]] | ||
[[Category: Outer membrane protein]] | [[Category: Outer membrane protein]] | ||
[[Category: Polypeptide transport-associated]] | [[Category: Polypeptide transport-associated]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 17:07, 25 December 2014
Crystal structure of TamA POTRA domains 1-3 from E. coli
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