4i92

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4i92| PDB=4i92 | SCENE= }}
+
==Structure of the BSK8 kinase domain==
-
===Structure of the BSK8 kinase domain===
+
<StructureSection load='4i92' size='340' side='right' caption='[[4i92]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_23911552}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4i92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I92 FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i93|4i93]], [[4i94|4i94]]</td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At5g41260, K1O13.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
 +
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i92 RCSB], [http://www.ebi.ac.uk/pdbsum/4i92 PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Brassinosteroid signaling kinases (BSKs) are plant-specific receptor-like cytoplasmic protein kinases involved in the brassinosteroid signaling pathway. Unlike common protein kinases, they possess a naturally occurring alanine residue at the "gatekeeper" position, as well as other sequence variations. How BSKs activate downstream proteins such as BSU1, as well as the structural consequences of their unusual sequential features, was unclear. We crystallized the catalytic domain of BSK8 and solved its structure by multiple-wavelength anomalous dispersion phasing methods to a resolution of 1.5A. In addition, a co-crystal structure of BSK8 with 5-adenylyl imidodiphosphate (AMP-PNP) revealed unusual conformational arrangements of the nucleotide phosphate groups and catalytic key motifs, typically not observed for active protein kinases. Sequential analysis and comparisons with known pseudokinase structures suggest that BSKs represent constitutively inactive protein kinases that regulate brassinosteroid signal transfer through an allosteric mechanism.
-
==About this Structure==
+
Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture.,Grutter C, Sreeramulu S, Sessa G, Rauh D J Mol Biol. 2013 Aug 2. pii: S0022-2836(13)00482-8. doi:, 10.1016/j.jmb.2013.07.034. PMID:23911552<ref>PMID:23911552</ref>
-
[[4i92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I92 OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:023911552</ref><references group="xtra"/><references/>
+
</div>
 +
 
 +
==See Also==
 +
*[[Pseudoenzyme|Pseudoenzyme]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Arath]]
[[Category: Arath]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
-
[[Category: Gruetter, C.]]
+
[[Category: Gruetter, C]]
-
[[Category: Rauh, D.]]
+
[[Category: Rauh, D]]
[[Category: Alanine gatekeeper]]
[[Category: Alanine gatekeeper]]
[[Category: Cfg]]
[[Category: Cfg]]

Revision as of 13:01, 4 January 2015

Structure of the BSK8 kinase domain

4i92, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools