2q9c
From Proteopedia
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| - | [[Image:2q9c.jpg|left|200px]] | + | [[Image:2q9c.jpg|left|200px]] |
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| - | '''Structure of FTSY:GMPPNP with MGCL Complex''' | + | {{Structure |
| + | |PDB= 2q9c |SIZE=350|CAPTION= <scene name='initialview01'>2q9c</scene>, resolution 2.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER'>GNP</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of FTSY:GMPPNP with MGCL Complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2Q9C is a [ | + | 2Q9C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9C OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates., Reyes CL, Rutenber E, Walter P, Stroud RM, PLoS ONE. 2007 Jul 11;2(7):e607. PMID:[http:// | + | X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates., Reyes CL, Rutenber E, Walter P, Stroud RM, PLoS ONE. 2007 Jul 11;2(7):e607. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17622352 17622352] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermus aquaticus]] | [[Category: Thermus aquaticus]] | ||
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[[Category: srp]] | [[Category: srp]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:23:20 2008'' |
Revision as of 16:23, 20 March 2008
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| , resolution 2.20Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | ftsY (Thermus aquaticus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of FTSY:GMPPNP with MGCL Complex
Overview
The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes. Conserved active site residues in the GTPase domains of both SRP and SR mediate discrete conformational changes during formation and dissociation of the SRP.SR complex. Here, we describe structures of the prokaryotic SR, FtsY, as an apo protein and in two different complexes with a non-hydrolysable GTP analog (GMPPNP). These structures reveal intermediate conformations of FtsY containing GMPPNP and explain how the conserved active site residues position the nucleotide into a non-catalytic conformation. The basis for the lower specificity of binding of nucleotide in FtsY prior to heterodimerization with the SRP conjugate Ffh is also shown. We propose that these structural changes represent discrete conformational states assumed by FtsY during targeting complex formation and dissociation.
About this Structure
2Q9C is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
Reference
X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates., Reyes CL, Rutenber E, Walter P, Stroud RM, PLoS ONE. 2007 Jul 11;2(7):e607. PMID:17622352
Page seeded by OCA on Thu Mar 20 18:23:20 2008
Categories: Single protein | Thermus aquaticus | Reyes, C L. | Stroud, R M. | GNP | SO4 | Cell cycle | Cell division | Ffh | Ftsy | Gdp | Gtp-binding | Gtpase | Inner membrane | Membrane | Nucleotide-binding | Ribonucleoprotein | Rna-binding | Signal recognition particle | Srp
