4bqk

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'''Unreleased structure'''
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{{STRUCTURE_4bqk| PDB=4bqk | SCENE= }}
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===rice importin_alpha : VirD2NLS complex===
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The entry 4bqk is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IMA1A_ORYSJ IMA1A_ORYSJ]] Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.<ref>PMID:9727027</ref> <ref>PMID:11124253</ref> [[http://www.uniprot.org/uniprot/VIRD2_AGRT5 VIRD2_AGRT5]] Tumor formation by A.tumefaciens involves the transfer and integration of a defined segment (T-DNA) of Ti plasmid DNA into the plant nuclear genome. The virD operon encodes a site-specific endonuclease that cleaves at a unique site within both 24 bp direct repeats flanking the T-DNA.
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Authors: Chang, C.-W., Counago, R.M., Williams, S.J., Kobe, B.
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==About this Structure==
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[[4bqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQK OCA].
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Description: rice importin_alpha : VirD2NLS complex
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==Reference==
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<ref group="xtra">PMID:024503158</ref><references group="xtra"/><references/>
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[[Category: Chang, C W.]]
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[[Category: Counago, R M.]]
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[[Category: Kobe, B.]]
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[[Category: Williams, S J.]]
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[[Category: Hydrolase]]
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[[Category: Nuclear localization signal]]
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[[Category: Transport protein]]

Revision as of 17:13, 19 February 2014

Template:STRUCTURE 4bqk

Contents

rice importin_alpha : VirD2NLS complex

Function

[IMA1A_ORYSJ] Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.[1] [2] [VIRD2_AGRT5] Tumor formation by A.tumefaciens involves the transfer and integration of a defined segment (T-DNA) of Ti plasmid DNA into the plant nuclear genome. The virD operon encodes a site-specific endonuclease that cleaves at a unique site within both 24 bp direct repeats flanking the T-DNA.

About this Structure

4bqk is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chang CW, Williams SJ, Counago RM, Kobe B. Structural Basis of Interaction of Bipartite Nuclear Localization Signal from Agrobacterium VirD2 with Rice Importin-alpha Mol Plant. 2014 Feb 6. PMID:24503158 doi:http://dx.doi.org/10.1093/mp/ssu014
  1. ↑ Jiang CJ, Imamoto N, Matsuki R, Yoneda Y, Yamamoto N. Functional characterization of a plant importin alpha homologue. Nuclear localization signal (NLS)-selective binding and mediation of nuclear import of nls proteins in vitro. J Biol Chem. 1998 Sep 11;273(37):24083-7. PMID:9727027
  2. ↑ Jiang CJ, Shoji K, Matsuki R, Baba A, Inagaki N, Ban H, Iwasaki T, Imamoto N, Yoneda Y, Deng XW, Yamamoto N. Molecular cloning of a novel importin alpha homologue from rice, by which constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported. J Biol Chem. 2001 Mar 23;276(12):9322-9. Epub 2000 Dec 20. PMID:11124253 doi:http://dx.doi.org/10.1074/jbc.M006430200

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